Table I.
Characteristics and biochemical parameters in treated groups on day 56
| Parameters | Control group (n = 8) | Control + Fe group (n = 8) | Uremic group (n = 6) | Uremic + Fe group (n = 6) |
|---|---|---|---|---|
| SBP (mmHg) | 121.9 ± 3.7 | 126.3 ± 10.8 | 131.7 ± 204 | 116.1 ± 9.3 |
| BW (g) | 534.4 ± 21.9 | 503.9 ± 20.7 | 294.5 ± 29.9a | 296.8 ± 33.4a,b |
| Cr (mg/dl) | 0.33 ± 0.03 | 0.34 ± 0.03 | 3.36 ± 0.74a | 2.96 ± 0.84a,b |
| Ht (%) | 53.9 ± 2.4 | 52.3 ± 3.1 | 27.9 ± 6.3a | 25.7 ± 3.3a,b |
| Fe (μg/dl) | 181.8 ± 36.6 | 323.1 ± 95.9a | 146.0 ± 32.0 | 291.2 ± 47.8a,b |
| TS (%) | 27.5 ± 6.2 | 49.2 ± 12.7a | 40.2 ± 4.60 | 82.2 ± 14.1b,c |
| Ferritin (ng/ml) | 2,618.8 ± 496.6 | 9,883.5 ± 3,757.5a | 1,753.3 ± 491.4 | 15,116.7 ± 6,724.1b,c |
| Corrected Ca (mg/dl) | 11.6 ± 0.37 | 12.3 ± 0.46 | 8.73 ± 1.53a | 8.97 ± 1.15a,b |
| Pi (mg/dl) | 9.03 ± 0.56 | 8.95 ± 0.59 | 17.35 ± 3.06a | 15.28 ± 3.54a,b |
| ALT (mg/dl) | 70.5 ± 29.5 | 138.63 ± 98.1 | 52.5 ± 24.5 | 63 67 ± 60.8 |
| AST (mg/dl) | 116.6 ± 31.6 | 204.5 ± 145.7 | 62.3 ± 11.4a | 91.5 ± 66.3a,b |
| Intact PTH (pg/ml) | 6,111.5 ± 1,578.3 | 425.1 ± 385.2 | 24,533.3 ± 9,575.7a,b | 21,790.0 ± 10,449.0a,b |
| 25(OH)D3 (ng/ml) | 32.6 ± 5.15 | 32.0 ± 9.4 | 31.8 ± 13.0 | 33.6 ± 14.7 |
| l,25(OH)2D3 (pg/ml) | 133.0 ± 20.1 | 133.2 ± 27.1 | 24.0 ± 8.1a,b | 99.8 ± 107.1c |
| FGF23 (pg/ml) | 56.8 ± 12.2 | 103.1 ± 22.6 | 74,502.0 ± 10,046.2a,b | 2,672 4 ± 3,394.8c |
SBP systolic blood pressure, BW body weight Cr serum creatinine, Ht hematocrit, Fe serum iron, TS transferrin saturation, Ca calcium, Pi inorganic phosphate, ALT alanine aminotransferase, AST aspartate aminotransferase
a p < 0.05 vs. the control group, b p < 0.05 vs. the control + Fe group, c p < 0.05 vs. the uremic group All data are given as mean ± SD