Fig. 1.

Schematic representation of the different cell signaling components affected by mutations in human CHD disease genes. These include ligands (L), receptors (R), down-stream effectors (E), transcription regulators, which include transcription factors (TF), transcription co-factors (co-TF) and histone modifying proteins (HM), and target genes. Known human CHD disease genes within the six groups are shown in the panel at the right. Colored figure are shown in the on-line version of the article