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. 2014 Jan 28;15(2):2024–2052. doi: 10.3390/ijms15022024

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© 2014 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — Activation of A₃AR suppresses ROS generation in AT6.1 prostate cancer cells. Cells were pretreated with the A₃AR agonist, IB-MECA, the antagonist, MRS1523, or a combination of IB-MECA + MRS1523. ROS was determined by H₂DCFDA fluorescence. IB-MECA significantly reduced fluorescence in these cells (A,B) which was reversed by MRS1523, indicating a role of the A₃AR in this process. Similar effects were obtained with DPI and AEBSF, known inhibitors of NADPH oxidase (C,D). Experiments were replicated four times. Histograms represent the mean ± SEM. Asterisks (*) and (**) indicates statistically significant difference (p < 0.05) from vehicle and IB-MECA treatments, respectively. (Reprinted with permission from [169], Copyright 2009 Neoplasia Press, Inc.).