Table 2.
Logistic regression analysis of associations between E26 transformation-specific-1 (ETS1) rs1128334 G/A and WDFY4 rs7097397 A/G polymorphisms and risk of rheumatoid arthritis.
| Genotype | Cases (n = 329) | Controls (n = 697) | Crude OR (95% CI) | p | Adjusted OR (95% CI) | p | ||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| n | % | n | % | |||||
| ETS1 rs1128334 G/A | ||||||||
|
| ||||||||
| G allele | 412 | 64.6 | 880 | 65.4 | 1.00 | – | ||
| A allele | 226 | 35.4 | 466 | 34.6 | 1.04 (0.85–1.26) | 0.726 | ||
| GG | 135 | 42.3 | 291 | 43.2 | 1.00 | – | 1.00 | – |
| GA | 142 | 44.5 | 298 | 44.3 | 1.03 (0.77–1.37) | 0.854 | 1.02 (0.76–1.35) | 0.921 |
| AA | 42 | 13.2 | 84 | 12.5 | 1.08 (0.71–1.65) | 0.729 | 1.06 (0.69–1.62) | 0.792 |
| AA vs. GA vs. GG | 0.939 | |||||||
| GA + AA | 184 | 57.7 | 382 | 56.8 | 1.04 (0.79–1.36) | 0.785 | 1.02 (0.78–1.34) | 0.862 |
| GG + GA | 277 | 86.8 | 589 | 87.5 | 1.00 | – | 1.00 | – |
| AA | 42 | 13.2 | 84 | 12.5 | 1.06 (0.72–1.58) | 0.762 | 1.05 (0.71–1.57) | 0.807 |
|
| ||||||||
| WDFY4 rs7097397 A/G | ||||||||
|
| ||||||||
| A allele | 404 | 62.9 | 933 | 67.5 | 1.00 | – | ||
| G allele | 238 | 37.1 | 449 | 32.5 | 1.22 (1.01–1.49) | 0.043 | ||
| AA | 122 | 38.0 | 324 | 46.9 | 1.00 | – | 1.00 | – |
| AG | 160 | 49.8 | 285 | 41.2 | 1.49 (1.12–1.98) | 0.006 | 1.50 (1.13–1.99) | 0.005 |
| GG | 39 | 12.1 | 82 | 11.9 | 1.26 (0.82–1.95) | 0.292 | 1.26 (0.82–1.95) | 0.294 |
| GG vs. AG vs. AA | 0.022 | |||||||
| AG + GG | 199 | 62.0 | 367 | 53.1 | 1.44 (1.10–1.89) | 0.008 | 1.45 (1.10–1.90) | 0.008 |
| AA + AG | 282 | 87.9 | 609 | 88.1 | 1.00 | – | 1.00 | – |
| GG | 39 | 12.1 | 82 | 11.9 | 1.03 (0.68–1.54) | 0.897 | 1.02 (0.68–1.54) | 0.911 |
The genotyping was successful in: 319 cases and 673 controls for ETS1 rs1128334 G/A; 321 cases and 691 controls for WDFY4 rs7097397 A/G. Adjusted for age and sex.