Table 3.
Variable | ETS1 rs1128334 G/A (Case/Control) | OR (95% CI) | WDFY4 rs7097397 A/G (Case/Control) | OR (95% CI) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||||
GG | GA | AA | GG | GA | AA | AA | AG | GG | AA | AG | GG | |
Gender | ||||||||||||
| ||||||||||||
Male | 33/99 | 37/75 | 8/20 | 1.00 | 1.48 (0.85–2.58); p:0.168 | 1.20 (0.48–2.98); p:0.695 | 33/87 | 39/88 | 9/22 | 1.00 | 1.17 (0.67–2.03); p:0.579 | 1.08 (0.45–2.58); p:0.865 |
Female | 102/192 | 105/223 | 34/64 | 1.00 | 0.89 (0.64–1.24); p:0.479 | 1.00 (0.62–1.62); p:1.000 | 89/237 | 121/197 | 30/60 | 1.00 | 1.64 (1.17–2.28); p:0.0037 | 1.33 (0.81–2.20); p:0.263 |
| ||||||||||||
Age | ||||||||||||
| ||||||||||||
<55 | 69/143 | 68/156 | 23/34 | 1.00 | 0.90 (0.60–1.35); p:0.623 | 1.40 (0.77–2.56); p:0.271 | 55/176 | 79/130 | 26/34 | 1.00 | 1.95 (1.29–2.94); p:0.0016, pcorrect:0.0032 | 2.45 (1.35–4.43); p:0.0031, pcorrect:0.0062 |
≥55 | 66/148 | 74/142 | 19/50 | 1.00 | 1.17 (0.78–1.75); p:0.450 | 0.85 (0.47–1.56); p:0.603 | 67/148 | 81/155 | 13/48 | 1.00 | 1.15 (0.78–1.71); p:0.476 | 0.60 (0.30–1.18); p:0.137 |
| ||||||||||||
CRP status | ||||||||||||
| ||||||||||||
Positive | 67/291 | 72/298 | 20/84 | 1.00 | 1.05 (0.73–1.52); p:0.799 | 1.03 (0.59–1.80); p:0.906 | 65/324 | 82/285 | 13/82 | 1.00 | 1.43 (1.00–2.06); p:0.051 | 0.79 (0.42–1.50); p:0.473 |
Negative | 68/291 | 70/298 | 22/84 | 1.00 | 1.01 (0.69–1.46); p:0.978 | 1.12 (0.65–1.92); p:0.678 | 57/324 | 78/285 | 26/82 | 1.00 | 1.56(1.07–2.27); p:0.0216 pcorrect:0.0432 |
1.80 (1.07–3.04); p:0.0273 pcorrect:0.0546 |
| ||||||||||||
ACPA status | ||||||||||||
| ||||||||||||
Positive | 66/291 | 76/298 | 17/84 | 1.00 | 1.12 (0.78–1.62); p:0.531 | 0.89 (0.50–1.60); p:0.703 | 61/324 | 80/285 | 19/82 | 1.00 | 1.49 (1.03–2.16); p:0.0340 pcorrect:0.0680 |
1.23 (0.70–2.17); p:0.475 |
Negative | 69/291 | 66/298 | 25/84 | 1.00 | 0.93 (0.64–1.36); p:0.721 | 1.26 (0.75–2.11); p:0.390 | 61/324 | 80/285 | 20/82 | 1.00 | 1.49 (1.03–2.16); p:0.0340 pcorrect:0.0680 |
1.30 (0.74–2.27); p:0.365 |
The genotyping was successful in: 319 cases and 673 controls for ETS1 rs1128334 G/A; 321 cases and 691 controls for WDFY4 rs7097397 A/G; Bonferroni correction was performed to correct the p value (pcorrect).