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Cytotoxicities of VCR, VRP, VCR/VRP against drug-sensitive cells and drug-resistant cells (n = 3).
| Cells | Drugs | IC50 values (nM) | Reversal index | CI values at IC50 |
|---|---|---|---|---|
| MCF-7 | VCR | 8.79 ± 0.63 | – | |
| MCF-7/ADR | VCR | 1202.55 ± 292.51 | – | |
| VRP | 98214.10 ± 4907.65 | – | ||
| VCR + 5 μM VRP | 16.25 ± 3.47 A | 74.00 | 0.0136 | |
| VCR + 10 μM VRP | 9.21 ± 2.06 A | 130.59 | 0.00776 | |
| VCR + 20 μM VRP | 7.69 ± 2.93 A | 156.34 | 0.0066 | |
| VCR + 50 μM VRP | 8.34 ± 2.71 A | 144.16 | 0.00744 |
p < 0.05, compared to free VCR.
