Table 4.
The LD0, LD50 and LD100 values of VCR-VRP-PLGANPs in comparison with VRP, free VCR/VRP combinations, VRP-PLGANPs and single-drug nanoparticle combinations.
| Drugs | Dose (mg/kg) | ||
|---|---|---|---|
|
| |||
| LD0 | LD100 | LD50 (Mean ± SD) | |
| VRP | 2.50 | 16.00 | 5.99 ± 0.83 |
| VCR/VRP | 2.18 | 13.00 | 4.93 ± 0.93 |
| VRP-PLGANPs | 3.83 | 12.66 | 8.44 ± 1.11 A |
| VCR-PLGANPs + VRP-PLGANPs | 3.56 | 13.95 | 7.85 ± 0.71 B |
| VCR-VRP-PLGANPs | 4.18 | 14.67 | 8.52 ± 1.54 B |
A
p < 0.05, compared to free VRP group;
B
p < 0.05, compared to free VCR/VRP combinations group.