Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb 20;15(2):2916–2928. doi: 10.3390/ijms15022916

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Figure 6. — Proposed model of inflammatory cascades induced by CRT in macrophages. CRT may bind to surface receptors such as SRA on macrophages and triggers (possibily after internaliation) the activation of IκBα-NFκB, p-JNK and p-ERK. IκBα-NFκB and p-JNK mediate the production of TNF-α and IL-6, while p-ERK is only involved in IL-6 expression.