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. 2014 Feb 20;15(2):2946–2958. doi: 10.3390/ijms15022946

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© 2014 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — TIA1/TIAL1 regulates the SIRT1-ΔExon8 mRNA levels in 293T cells detected by Real-Time PCR. (A) The TIA1/TIAL1 protein levels after TIA1/TIAL1 overexpression or silencing in 293T cells; (B) Over-expression of TIA1/TIAL1 decreased the levels of SIRT1-ΔExon8 for about 60% and 70%, respectively; (C) The levels of SIRT1-FL and SIRT1-ΔExon8 mRNA had no significant differences after depletion of either TIA1 or TIAL1; (D) Reducing the levels of TIA1 and TIAL1 simultaneously resulted in SIRT1-ΔExon8 increase. ^* p < 0.05 compared to transfect corresponding vector control.