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. 2014 Feb 20;15(2):2946–2958. doi: 10.3390/ijms15022946

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© 2014 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 4. — HuR and TIA1/TIAL1 regulated the alternative splicing of SIRT1 exon 8 in UV injury model. (A) The changes of HuR and TIA1/TIAL1 mRNAs under UV injury (10 j/m²) condition. The level of HuR was markedly increased after UV exposure, while the level of TIA1 or TIAL1 was decreased; (B) The change of SIRT1-ΔExon8 mRNA after HuR or TIA1/TIAL1 over-expression or depletion respectively under UV injury condition; (C) The levels of SIRT1-FL mRNA no significant change. ^* p < 0.05 compared to transfect corresponding vector control.

Figure 4. — HuR and TIA1/TIAL1 regulated the alternative splicing of SIRT1 exon 8 in UV injury model. (A) The changes of HuR and TIA1/TIAL1 mRNAs under UV injury (10 j/m²) condition. The level of HuR was markedly increased after UV exposure, while the level of TIA1 or TIAL1 was decreased; (B) The change of SIRT1-ΔExon8 mRNA after HuR or TIA1/TIAL1 over-expression or depletion respectively under UV injury condition; (C) The levels of SIRT1-FL mRNA no significant change. ^* p < 0.05 compared to transfect corresponding vector control.