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Half-lives of tertiary amine side chain terminated derivatives of PatA in cell culture media
| compd conc. | 2 1 μM |
2 10 μM |
9b 10 μM |
9c 10 μM |
|
|---|---|---|---|---|---|
| t1/2 (h) | HBAB | 24.0 ± 2.08 | 13.0 ± 1.01 | 17.8 ± 1.63 | 11.7 ± 0.15 |
| FBS | 19.9 ± 1.57 | 12.5 ± 0.81 | 9.23 ± 0.28 | 14.8 ± 0.82 | |
| RPMI | 5.11 ± 0.12 | 3.25 ± 0.28 | 0.89 ± 0.043 | 3.87 ± 0.58 |
HBAB: human blood serum and RPMI media
FBS: fetal bovine serum and RPMI media
RPMI: (control) RPMI media only
Half-lives are reported with ± 1 standard deviation
