Table 3.

Significantly modulated mRNA genes^#

mRNA	Fold-change	mRNA	Fold-change	mRNA	Fold-change
CXCL10	641.36	IL1R2	4.36	CCR8	−2.11
CXCL9	394.81	ITGB2	4.36	CCR4	−2.11
CCL2	279.17	CXCL1	4.07	CCL1	−2.11
CCL5	113.38	CCR7	3.80	CCL20	−2.11
CCL7	85.92	NFKBIA	3.36	CCL24	−2.11
CCL12	65.12	HMOX1	3.36	IL13	−2.11
CCR2	40.09	IL1β	3.31	IL1F6	−2.11
CCL8	21.48	FOS	3.14	IL1F8	−2.11
CCL4	20.04	RUNX1	2.93	IL20	−2.11
CCL3	17.45	S100A8	2.73	XCR1	−2.11
CXCL13	17.45	BCL2L1	2.56	LTA	−2.21
IL10	12.34	TXNIP	2.55	IL3	−2.21
IL2RG	12.34	IL1R1	2.54	IL4	−2.21
IFNγ	10.02	CCR9	2.51	IL5RA	−2.21
CXCL11	7.59	WFS1	2.38	BDNF	−2.38
CCL9	6.61	CEBPB	2.38	IL16	−2.42
CCR1	6.17	TNFRSF1B	2.34	IL17B	−2.42
TNF-α	6.17	CD40LG	2.34	PLG	−2.55
IL2RB	5.76	PTGS2	2.22	MYOD1	−2.55
C3	5.37	THBS1	2.22	AIPL1	−2.55
TNFSF10	5.10	CCR5	2.18	SMAD6	−2.56
CXCR3	5.01	MYC	2.08	EPHB2	−2.68
CCR3	5.01	BCL6	2.04	MSX2	−2.73
LTB	5.01	SERPINE1	2.03	PF4	−2.98
RBL1	4.44	SNAI1	2.03	CCR6	−5.56
CASP1	4.36	CRP	−2.11	ATF3	−6.73
CCL19	4.36	CXCL15	−2.11

^#Change in the levels of each gene was first normalized to the housekeeping genes and then the fold-change in WNV-infected brain was calculated in comparison to mock-infected brain.