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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Jun 2;1842(3):473–481. doi: 10.1016/j.bbadis.2013.05.029

Figure 2. Glucocorticoids simultaneously increase pathways of TG synthesis and breakdown.

Figure 2

A. GCs especially when added in the presence of insulin, mimicking the fed state, induce the expression of genes involved in lipid uptake (LPL), TG synthesis (LIPIN, AGPAT, DGAT1) and de novo lipogenesis (ACC, FAS). GCs also increase the expression of genes involved in TG hydrolysis (ATGL, HSL, MGL). GC induction of PCK1 expression is likely to play a role in glyceroneogenesis, contributing to TG synthetic pathway. B. GCs increase lipid turnover in adipose tissue. While GCs are widely cited as lipolytic and thought to increase systemic FFA, they also increase lipid uptake and TG synthesis. Factors that tip this balance toward TG synthesis in a depot-dependent manner may lead to hypertrophy of existing adipocytes and hence affect regional adiposity.