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. Author manuscript; available in PMC: 2014 Mar 19.

Published in final edited form as: Circ Res. 2013 Oct 29;114(1):41–55. doi: 10.1161/CIRCRESAHA.114.302500

A and B: Three examples of Pimo^pos (A, white) and one example of Pimo^neg (B) c-kit-positive CSCs (green). Myocytes are stained by α-sarcomeric actin (α-SA, red). C: Pimo^pos (white) c-kit-positive CSCs are surrounded by Pimo^pos fibroblasts (procollagen, yellow) and Pimo^neg cardiomyocytes. D: HIF-1α (magenta) is present in Pimo^pos-CSCs and Pimo^neg cardiomyocytes (α-SA, red; arrows). The area in the rectangle is shown at higher magnification in the insets. E: CAIX (magenta) is restricted to Pimo^pos-CSCs. Labeling for c-kit, Pimo, and CAIX are shown at higher magnification in the insets. F: HIF-1α (magenta) is present in a cluster of Pimo^neg-CSCs (arrows).

A and B: Three examples of Pimo^pos (A, white) and one example of Pimo^neg (B) c-kit-positive CSCs (green). Myocytes are stained by α-sarcomeric actin (α-SA, red). C: Pimo^pos (white) c-kit-positive CSCs are surrounded by Pimo^pos fibroblasts (procollagen, yellow) and Pimo^neg cardiomyocytes. D: HIF-1α (magenta) is present in Pimo^pos-CSCs and Pimo^neg cardiomyocytes (α-SA, red; arrows). The area in the rectangle is shown at higher magnification in the insets. E: CAIX (magenta) is restricted to Pimo^pos-CSCs. Labeling for c-kit, Pimo, and CAIX are shown at higher magnification in the insets. F: HIF-1α (magenta) is present in a cluster of Pimo^neg-CSCs (arrows).