Table 2.

Simulation results for the estimated breadth using the empirical method, ABH and q-value methods. Estimates are computed as averages over the 1000 simulated data sets. The FDR level is 10%. qval.s represents the q-value method using the natural cubic spline smoother for choosing λ, and qval.b represents the q-value method using the bootstrap for choosing λ.

				IC50			AUC
Case	B	Method	Empirical	ABH	qval.s	qval.b	ABH	qval.s	qval.b
σ = 0.05
1	0	B̂mo	-	0.0	0.0	0.0	0.0	0.0	0.0
		B̂V+T	0.6	0.0	0.0	0.0	0.0	0.0	0.0
2	10	B̂mo	-	3.5	0.0	4.0	5.8	0.0	6.8
		B̂V+T	9.0	5.1	5.0	5.1	7.5	7.3	7.5
3	10	B̂mo	-	7.7	0.0	3.3	8.0	0.0	1.4
		B̂V+T	10.2	9.2	9.2	9.2	10.0	10.0	10.0
σ = 0.10
1	0	B̂mo	-	0.0	0.0	0.0	0.0	0.0	0.0
		B̂V+T	1.1	0.1	0.1	0.1	0.0	0.0	0.0
2	10	B̂mo	-	2.9	0.0	3.1	3.3	0.0	4.0
		B̂V+T	8.7	4.4	4.4	4.4	4.3	4.2	4.3
3	10	B̂mo	-	7.4	0.0	3.2	7.8	0.0	5.5
		B̂V+T	10.5	9.1	9.0	9.1	9.8	9.7	9.8