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. Author manuscript; available in PMC: 2014 Mar 19.
Published in final edited form as: J Orthop Res. 2012 Jul 26;31(1):91–98. doi: 10.1002/jor.22191

Figure 4.

Figure 4

Collagen remodeling 6, 12 and 24 hours after release of lattices (control-, SP- (10−7 M), and NK-1 R inhibitor (10−6 M) & SP- (10−7 M)- treated). The extent of remodeling in the SP treated group was increased compared to control at 6 and 12 hours (6h ***p<0.001, 12h ***p<0.001, 2-way ANOVA, followed by Bonferroni post-hoc test). The inhibitor temporary blocked the effects of SP at 12h but the effect was incomplete at 6h compared to control (*p<0.05, 2-way ANOVA, followed by Bonferroni post-hoc test). At 12h, treatment with SP resulted in significant increase in remodeling while treatment of the inhibitor blocked the effect (***p<0.001, 2-way ANOVA, followed by Bonferroni post-hoc test).

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