Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Nausea
RCT 3-armed trial	60 women, mean gestational age ranged from 9.6–10.8 weeks In review	Mean nausea score assessed on visual analogue scale (0 = no nausea, 10 = extreme nausea) 1 day post treatment commencement 5.2 with P6 wristband acupressure for 2 weeks 5.6 with placebo wristband acupressure on upper surface of wrist for 2 weeks 7.6 with no treatment	P = 0.002 acupressure v no treatment		P6 acupressure
RCT 3-armed trial	60 women, mean gestational age ranged from 9.6–10.8 weeks In review	Mean nausea score assessed on visual analogue scale (0 = no nausea, 10 = extreme nausea) 3–6 days 5.6–4.9 with P6 wristband acupressure for 2 weeks 5.5–6.3 with placebo wristband acupressure on upper surface of wrist for 2 weeks	P = 0.013		P6 acupressure
RCT	80 pregnant women within the first trimester with moderate to severe nausea and vomiting	Median nausea score assessed on 10 cm visual analogue scale (0 = lack of nausea, 10 = severe nausea) 1 day 7 with acupressure at KID21 point applied for 4 consecutive days 7 with sham acupressure (non-acupuncture point) applied for 4 consecutive days	P = 0.473		Not significant
RCT	80 pregnant women within the first trimester with moderate to severe nausea and vomiting	Median nausea score assessed on 10 cm visual analogue scale (0 = lack of nausea, 10 = severe nausea) 2 days 6 with acupressure at KID21 point applied for 4 consecutive days 7 with with sham acupressure (non-acupuncture point) applied for 4 consecutive days	P = 0.012		acupressure
RCT	80 pregnant women within the first trimester with moderate to severe nausea and vomiting	Median nausea score assessed on 10 cm visual analogue scale (0 = lack of nausea, 10 = severe nausea) 3 days 5 with acupressure at KID21 point applied for 4 consecutive days 7 with sham acupressure (non-acupuncture point) applied for 4 consecutive days	P <0.001		acupressure
RCT	80 pregnant women within the first trimester with moderate to severe nausea and vomiting	Median nausea score assessed on 10 cm visual analogue scale (0 = lack of nausea, 10 = severe nausea) 4 days 4 with acupressure at KID21 point applied for 4 consecutive days 7 with sham acupressure (non-acupuncture point) applied for 4 consecutive days	P <0.001		acupressure
Vomiting
RCT	80 pregnant women within the first trimester with moderate to severe nausea and vomiting	Median frequency of vomiting 1 day 1 with acupressure at KID21 point applied for 4 consecutive days 1 with sham acupressure (non-acupuncture point) applied for 4 consecutive days	P = 0.012		acupressure
RCT	80 pregnant women within the first trimester with moderate to severe nausea and vomiting	Median frequency of vomiting 2 days 0 with acupressure at KID21 point applied for 4 consecutive days 1 with sham acupressure (non-acupuncture point) applied for 4 consecutive days	P = 0.003		acupressure
RCT	80 pregnant women within the first trimester with moderate to severe nausea and vomiting	Median frequency of vomiting 3 days 0 with acupressure at KID21 point applied for 4 consecutive days 1 with sham acupressure (non-acupuncture point) applied for 4 consecutive days	P = 0.001		acupressure
RCT	80 pregnant women within the first trimester with moderate to severe nausea and vomiting	Median frequency of vomiting 4 days 0 with acupressure at KID21 point applied for 4 consecutive days 1 with sham acupressure (non-acupuncture point) applied for 4 consecutive days	P <0.001		acupressure
Nausea and vomiting (composite)
RCT	97 women, 8–12 weeks' gestation In review	Mean change from baseline in hours of nausea and vomiting 12 days –2.74 with active wristband acupressure –0.85 with sham wristband acupressure	MD 1.89 95% CI 0.33 to 3.45 P = 0.018	Effect size not calculated	active wristband acupressure
RCT	97 women, 8–12 weeks' gestation In review	Mean change from baseline in nausea and vomiting assessed on visual analogue scale 12 days –0.50 with active wristband acupressure –0.25 with sham wristband acupressure	MD +0.25 95% CI –0.12 to +0.62		Not significant
Systematic review	97 women, 8–12 weeks' gestation Data from 1 RCT	Proportion of participants reporting no improvement in intensity of symptoms 15/53 (28%) with active wristband acupressure 16/44 (36%) with sham wristband acupressure	RR 0.78 95% CI 0.44 to 1.39 P = 0.40		Not significant
RCT	98 pregnant women, <14 weeks' gestation, with symptoms of nausea and vomiting In review	Mean Rhodes Index Scale day 4 8.7 with bilateral auricular acupressure (to the concha ridge zone of the inner auricle surface for 30 seconds 4 times a day on days 3–6) 10.6 with no treatment	P = 0.387		Not significant
RCT	98 pregnant women, <14 weeks' gestation, with symptoms of nausea and vomiting In review	Mean Rhodes Index Scale day 5 8.0 with bilateral auricular acupressure (to the concha ridge zone of the inner auricle surface for 30 seconds 4 times a day on days 3–6) 11.6 with no treatment	P = 0.274		Not significant
RCT	98 pregnant women, <14 weeks' gestation, with symptoms of nausea and vomiting In review	Mean Rhodes Index Scale day 6 7.7 with bilateral auricular acupressure (to the concha ridge zone of the inner auricle surface for 30 seconds 4 times a day on days 3–6) 11.3 with no treatment	P = 0.252		Not significant