Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Nausea and vomiting
RCT 3-armed trial	66 women diagnosed with hyperemesis gravidarum; gestational age range 5–30 weeks	Mean nausea and vomiting scores (assessed using modified form of full Rhodes Index score) third day after admission 17.57 with acupressure at the Neiguan point (P6) applied using the thumb for 10 minutes 3 times daily for 5–7 days 22.05 with placebo (acupressure applied around the radial pulse at the wrist) for 5–7 days 21.59 with control for 5–7 days	P = 0.014 for among-group difference See further information on studies for data on placebo v control Weak methods (see further information on studies)
RCT 3-armed trial	66 women diagnosed with hyperemesis gravidarum; gestational age range 5–30 weeks	Mean nausea and vomiting scores fourth day after admission 12.48 with acupressure at the Neiguan point (P6) applied using the thumb for 10 minutes 3 times daily for 5–7 days 19.38 with placebo (acupressure applied around the radial pulse at the wrist) for 5–7 days 17.91 with control for 5–7 days	P <0.001 for among-group difference See further information on studies for data on placebo v control Weak methods (see further information on studies)
RCT 3-armed trial	66 women diagnosed with hyperemesis gravidarum; gestational age range 5–30 weeks	Mean nausea and vomiting scores day of discharge 9.22 with acupressure at the Neiguan point (P6) applied using the thumb for 10 minutes 3 times daily for 5–7 days 14.67 with placebo (acupressure applied around the radial pulse at the wrist) for 5–7 days 13.05 with control for 5–7 days	P <0.001 for among-group difference See further information on studies for data on placebo v control Weak methods (see further information on studies)
RCT 3-armed trial	66 women diagnosed with hyperemesis gravidarum; gestational age range 5–30 weeks	Nausea and vomiting with acupressure with placebo	P <0.001 Absolute values not reported Unclear which data these results are based on		Acupressure
RCT 3-armed trial	66 women diagnosed with hyperemesis gravidarum; gestational age range 5–30 weeks	Nausea and vomiting with acupressure with control	P = 0.002 Absolute values not reported Unclear which data these results are based on		Acupressure