Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Vomiting
RCT	40 women with intractable hyperemesis gravidarum admitted to intensive care at <16 weeks' gestation	Reduction of mean number of vomiting episodes day 2 41% with intravenous hydrocortisone for 1 week 17% with intravenous metoclopramide for 1 week	P <0.0001	Effect size not calculated	hydrocortisone
RCT	40 women with intractable hyperemesis gravidarum admitted to intensive care at <16 weeks' gestation	Reduction of mean number of vomiting episodes day 3 72% with intravenous hydrocortisone for 1 week 51% with intravenous metoclopramide for 1 week	P <0.0001	Effect size not calculated	hydrocortisone
RCT	40 women with intractable hyperemesis gravidarum admitted to intensive care at <16 weeks' gestation	Reduction of mean number of vomiting episodes day 7 96% with intravenous hydrocortisone for 1 week 77% with intravenous metoclopramide for 1 week	P <0.0001	Effect size not calculated	hydrocortisone