Table 1. Parameters of the model and their default values.

Parameter	Default value	Interpretation	Reference
τ	29 min	Time delay in Hes1 protein production.	21
p0	390	Amount of protein required to reduce Hes1 mRNA transcription by half.
n0	5	Quantifies the step-like nature of G.	12
r0	100	Amount of miR-9 required to reduce Hes1 mRNA degradation rate by half.
m0	5	Quantifies the step-like nature of S.
bl	ln(2)/20 min−1	Lower bound for Hes1 mRNA half-life.	9
bu	ln(2)/35 min−1	Upper bound for Hes1 mRNA half-life	9
r1	300	Amount of miR-9 required to reduce Hes1 protein translation rate by half.
m1	5	Quantifies the step-like nature of F.
p1	Varies	Amount of protein required to reduce miR-9 production rate by half.
n1	5	Quantifies the step-like nature of Gr.
μr	1,000 min	Lumped half-life for free miR-9.
μp	22 min	Half-life of Hes1 protein.	11