Table 3.
HRs and excess risk of overweight and obesity mediated through different combinations of metabolic risk factors
|
Overweight |
Obesity |
|||
|---|---|---|---|---|
| HR (95% CI) | Excess risk mediated (%, 95% CI) | HR (95% CI) | Excess risk mediated (%, 95% CI) | |
| Coronary heart disease | ||||
| None | 1·26 (1·22 to 1·30) | .. | 1·69 (1·58 to 1·81) | .. |
| Blood pressure | 1·18 (1·14 to 1·22) | 31% (26 to 36) | 1·48 (1·39 to 1·57) | 31% (27 to 35) |
| Cholesterol | 1·21 (1·18 to 1·25) | 18% (13 to 22) | 1·64 (1·54 to 1·75) | 8% (2 to 12) |
| Blood glucose | 1·23 (1·18 to 1·27) | 12% (6 to 18) | 1·60 (1·49 to 1·72) | 14% (8 to 20) |
| Blood pressure and cholesterol | 1·14 (1·11 to 1·18) | 45% (40 to 52) | 1·44 (1·36 to 1·53) | 36% (33 to 40) |
| Blood pressure and blood glucose | 1·16 (1·12 to 1·20) | 38% (32 to 45) | 1·42 (1·34 to 1·51) | 39% (35 to 44) |
| Cholesterol and blood glucose | 1·19 (1·15 to 1·23) | 27% (22 to 33) | 1·55 (1·46 to 1·64) | 21% (17 to 25) |
| Blood pressure, cholesterol, and blood glucose | 1·13 (1·09 to 1·16) | 50% (44 to 58) | 1·39 (1·32 to 1·47) | 44% (41 to 48) |
| Stroke | ||||
| None | 1·13 (1·08 to 1·18) | .. | 1·47 (1·36 to 1·59) | .. |
| Blood pressure | 1·03 (0·99 to 1·07) | 76% (61 to 104) | 1·21 (1·13 to 1·28) | 56% (50 to 64) |
| Cholesterol | 1·11 (1·06 to 1·16) | 17% (5 to 30) | 1·44 (1·33 to 1·56) | 7% (−1 to 14) |
| Blood glucose | 1·09 (1·04 to 1·15) | 29% (13 to 55) | 1·35 (1·24 to 1·47) | 25% (18 to 34) |
| Blood pressure and cholesterol | 1·04 (0·99 to 1·08) | 74% (54 to 112) | 1·19 (1·12 to 1·27) | 59% (52 to 70) |
| Blood pressure and blood glucose | 1·01 (0·96 to 1·06) | 93% (67 to 147) | 1·15 (1·08 to 1·22) | 68% (62 to 76) |
| Cholesterol and blood glucose | 1·09 (1·04 to 1·15) | 31% (16 to 56) | 1·34 (1·24 to 1·45) | 28% (20 to 36) |
| Blood pressure, cholesterol, and blood glucose | 1·00 (0·96 to 1·05) | 98% (69 to 155) | 1·14 (1·08 to 1·21) | 69% (64 to 77) |
All HRs are relative to normal weight (BMI ≥20–<25 kg/m2), and were adjusted for confounders. HR=hazard ratio. BMI=body-mass index.