Table 4.
Stratified analyses of percentage of excess risk (95% CI) per 5 kg/m2 higher BMI mediated through the combination of blood pressure, cholesterol, and blood glucose
| CHD | Stroke | |
|---|---|---|
| Event type* | ||
| Combined fatal and non-fatal event | 50% (46–55) | 69% (60–81) |
| Fatal event | 39% (31–49) | 115%‡ (78–234‡) |
| Cohort location† | ||
| North America, western Europe, Australia and New Zealand | 44% (40–50) | 73% (57–96) |
| East and southeast Asia | 39% (31–49) | 79% (59–108‡) |
| Baseline year | ||
| <1990 | 53% (46–62) | 62% (51–78) |
| ≥1990 | 38% (34–44) | 93% (74–141‡) |
| Median age at baseline (years) | ||
| <55 | 45% (41–50) | 63% (53–74) |
| ≥55 | 46% (39–56) | 95% (73–149‡) |
| Follow-up years | ||
| <10 | 43% (35–52) | 89% (67–132‡) |
| 10 to 20 | 45% (40–52) | 84% (68–134‡) |
| >20 | 49% (40–59) | 52% (44–62) |
BMI=body-mass index.
*
Three cohorts reported their results for non-fatal coronary heart disease and non-fatal stroke.
†
Seven cohorts from other regions reported results for coronary heart disease, and six cohorts from other regions reported results for stroke.
‡
Hazard ratios of BMI were less than 1·0 after adjustment for mediators. Therefore, the numerator of percentage of excess risk mediated was greater than the denominator. This possible overadjustment itself could be due to residual and unmeasured confounding.