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When ionizing γ-radiation damages DNA of intestinal crypt cells, p53 induces cell cycle arrest for DNA repair. If the DNA damage is irreparable, p53 initiates cell death. Cellular RNA released from the cells, which underwent p53-mediated cell death after γ-irradiation, induces extensive crypt cell death via TLR3, leading to a deficient supply of intestinal epithelial cells, destruction of villous epithelium and death from GIS.
