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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Hippocampus. 2014 Jan 14;24(4):466–475. doi: 10.1002/hipo.22240

Figure 8.

Figure 8

DHPG-LTD does not require synaptic activation. A) Time course of changes in synaptic responses due to DHPG application for two pathways. DHPG induced a similar level of DHPG-LTD in the pathway that received continuous 0.033 Hz stimulation (Stimulated: filled circles, n = 6) during DHPG application and for the other pathway in which the basal stimulation was turned off during the 10 min of DHPG application and for the initial 10 min during drug washout (Unstimulated: open circles, n = 6). Inserts are representative traces of EPSP responses for the time points indicated in the figure for Stimulated (right) and Unstimulated (left) pathways. B) Bars show the mean+SEM DHPG-LTD at 30 and 40 min (dotted area in time course) after the start of DHPG washout for Stimulated (filled) and Unstimulated (open) pathways.