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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Pediatr Neurol. 2013 Dec 5;50(4):290–296. doi: 10.1016/j.pediatrneurol.2013.12.002

Figure 2.

Figure 2

Proposed model of TSC pathomechanism in the brain. Mutation of either TSC1 or TSC2 disrupts the inhibitory function of the TSC1/2 complex. This leads to constitutively increased mTORC1 activity, which in turn results in abnormal neuronal connectivity, characterized by abnormal neuronal morphology and migration, abnormal white matter and impaired synapse function.