Table 1. Frequency of pre-B and B cell tumors induced by the Eμ-Myc transgene.
Pre-B lymphoma*
|
B lymphoma*
|
|||
---|---|---|---|---|
Genotype | Frequency, % | Incidence at 11 wk,† % | Frequency, % | Incidence at 11 wk,† % |
Bim+/+ | 6 of 18 (33) | 11 | 12 of 18 (66) | 0 |
Bim+/— | 9 of 39 (23) | 10 | 30 of 39 (77)‡ | 22 |
Bim—/— | 3 of 11 (27) | 34 | 9 of 11 (73) | 57 |
Lymphomas were typed by flow cytometry of surface immunofluorescence: pre-B lymphoma (B220+ CD19+ IgM—); and B lymphoma (B220+ CD19+ IgM+)
Cumulative incidence at 11 wk of age. The other tumor type was censored, so the incidence shown is independent of the competing risk of the other type
The frequency of B lymphoma in Bim+/— versus Bim+/+ Eμ-Myc mice was not significantly different (P = 0.41)