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Conflicting asymmetry in PPA with TDP-type A and Alzheimer’s disease pathologies in right-handed Patient P16. Top: TDP-43 precipitates show rightward preponderance in the superior temporal gyrus (STG). Bottom: Thioflavin-S positive neurofibrillary tangles and neuritic plaques of Alzheimer pathology show the reverse asymmetry, in a pattern that is more concordant with the aphasic phenotype in a right-handed person. AD = Alzheimer’s disease.
