Figure 1.

RAD140 increases neuron viability against Aβ in a concentration-dependent manner. Neuron survival was measured in cultures pretreated with 0–100 nM T (A) and DHT (B); 0–300 nM RAD140 (C) and RAD192 (D) for 1 hour, followed by 24-hour exposure to 50 μM Aβ1–42 (solid bars). Cell viability data show the mean (± SEM) cell counts of viable cells expressed as percentage of vehicle-treated control group (C, open bar). *, P < .0001 relative to vehicle + AAII condition (0, solid bar); n ≥ 3.