Figure 2.

RAD140 is neuroprotective against apoptotic insults. Cultures were treated with 50 μM zVAD-fmk (A), 10 nM T (B), 100 nM RAD140 (C), or 100 nM RAD192 (D) for 1 hour, followed by exposure to 50 μM Aβ1–42, 3 μM AAII, or 25 μM H₂O₂ for 24 hours, and processed for cell viability. Data show mean (± SEM) cell viability expressed as percentage of vehicle-treated control (Veh, open bar). *, P < .001 relative to the corresponding vehicle-treated condition (gray bars); n ≥ 3.