Figure 5.

RAD140 reduces neuronal cell death cause by kainate. The extent of neuronal cell death in the CA2/3 region of the hippocampus following kainate lesion was determined qualitatively and quantitatively across groups. Images show representative thionin-stained sections of CA3 hippocampus from (A) nonlesioned sham-GDX rats and the following kainate-lesioned groups: B, Sham-GDX; C, GDX; D, GDX+T; E, GDX+RAD140. F, Neuron survival was quantified by counts of NeuN-immunoreactive cells. Data show mean (± SEM) counts expressed as a percentage of values from nonlesioned sham animals. *, P < .05 compared with nonlesioned sham-GDX; n ≥ 7 per condition.