Table 4.
Hazard ratios (95% confidence intervals) for age adjusted associations between defined daily doses (DDDs) of study drug (versus no study drugs) before and after adjusting for other potential confounders
| Variables | No of patients | Age adjusted hazard ratio (95% CI) | P value | Fully adjusted* hazard ratio (95% CI) | P value |
|---|---|---|---|---|---|
| DDDs (all study drugs): | |||||
| 0 | 69 418 | 1.00 | — | 1.00 | — |
| 1-30 | 10 275 | 1.89 (1.80 to 1.98) | <0.001 | 2.07 (1.97 to 2.17) | <0.001 |
| 31-60 | 6042 | 2.38 (2.25 to 2.51) | <0.001 | 2.58 (2.44 to 2.72) | <0.001 |
| 61-90 | 3207 | 2.39 (2.23 to 2.56) | <0.001 | 2.46 (2.29 to 2.63) | <0.001 |
| ≥91 | 15 203 | 1.77 (1.72 to 1.84) | <0.001 | 1.91 (1.84 to 1.98) | <0.001 |
| Any DDDs | 34 727 | 1.93 (1.87 to 1.98) | <0.001 | 2.08 (2.02 to 2.15) | <0.001 |
*Adjusted for age, sex, physical health problems (arthritis, asthma, cancer, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, diabetes, epilepsy, gastrointestinal disorders, hypertension, musculoskeletal disorders, anxiety disorders, sleep disorders, other (non-anxiety), psychiatric disorders, and prescriptions for non-study drugs.