Table 1.

 Sensitivity analyses of studies on antidepressant efficacy of agomelatine

Meta-analysis	No of studies	Effect size (95% CI)	I2 (%)
Agomelatine v placebo
Fixed effect model using final scores	12	0.23 (0.17 to 0.30)	66
Random effects model using changes scores	12	0.23 (0.12 to 0.34)	66
Random effects model using ANCOVA estimates (HAM-D scores only)	10	1.9 (0.94 to 2.87)*	68
Random effects model using raw HAM-D final scores	11	1.97 (1.12 to 2.82)†	60
Agomelatine v other antidepressant
Fixed effect model using final scores	13	1.00 (−0.06 to 0.06)	59
Random effects model using changes scores	13	−0.01 (−0.10 to 0.10)	56
Random effects model using raw HAM-D final scores	12	0.06 (−0.40 to 0.53)†	63

*Raw mean differences on HAM-D scale adjusted for baseline scores.

†Raw mean differences on HAM-D scale.