Table 2.

 Meta-regression of effect modifiers

Variable tested	Coefficient (95% CI)l	P value	Proportion (%) of variation explained by covariate
Agomelatine v placebo (12 studies)
Duration of treatment >6 weeks	0.04947 (−0.2158 to 0.3148)	0.687	−11.20
Low risk of bias	0.1043 (−0.1680 to 0.3766)	0.413	0.35
Allocation concealment	0.1652 (−0.0717 to 0.4021)	0.151	20.38
Agomelatine v antidepressant (13 studies)
Duration of treatment >6 weeks	−0.0333 (−0.2557 to 0.1891)	0.748	−15.98
Duration of current episode*	0.0006 (−0.0021 to 0.0033)	0.655	−33.93
Low risk of bias	0.0191 (−0.1886 to 0.2268)	0.843	−17.46
Allocation concealment	0.1645 (−0.0165 to 0.3456)	0.071	38.47

*12 studies.