Table 4.
Other meta-analyses of agomelatine v placebo or other antidepressants
| Reference | Placebo studies | Antidepressant comparator studies | |||
|---|---|---|---|---|---|
| Studies/participants* | Outcome | Studies/participants* | Outcome | ||
| Singh, 2011 | 5/1963 | Agomelatine effect size (SMD) v placebo†=0.26 | 5/1698 | Agomelatine effect size (SMD) v comparator†=0.11 | |
| Kasper, 2013 | Nil | NA | 6/2034 | Mean difference in HAM-d score change=0.86 points† | |
| Koesters, 2013 | 10/2896 | Agomelatine effect size (SMD) v placebo†=0.18 | Nil | NA | |
| Current study | 12/3951 | Agomelatine effect size (SMD) v placebo†=0.24 | 13/4559 | Agomelatine effect size (SMD) v comparator=0.00 | |
SMD=standardised mean difference; NA=not applicable.
*Number randomised.
†Agomelatine significantly better on measure described.