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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Neurobiol Learn Mem. 2013 Sep 18;113:41–54. doi: 10.1016/j.nlm.2013.09.007

Figure 5.

Figure 5

ERK phosphorylation is selectively increased in the amygdala following delay extinction and in the retrosplenial cortex following trace extinction. (A) Experimental design. Animals were sacrificed 30 minutes after extinction or retrieval on Day 2 (n=9–10 per group.) (B) ERK phosphorylation is upregulated in the amygdala following retrieval (4T) and extinction (EXT) of delay fear conditioning, but no change in ERK phosphorylation was observed following trace retrieval or extinction. (C) In the infralimbic cortex, ERK phosphorylation was upregulated following both delay and trace extinction. (D) No changes in ERK phosphorylation were observed in the dorsal hippocampus. (E) ERK phosphorylation in the prelimbic cortex was slightly increased following trace fear extinction, although this effect was not significant. No changes were observed in delay animals. (F) ERK phosphorylation was significantly increased in the retrosplenial cortex following trace fear extinction, but no change was observed following delay extinction. *p < 0.05, #p = 0.054, ^p = 0.533, not significant. DFC, delay fear conditioning; TFC, trace fear conditioning; pERK, phosphorylated ERK; totERK, total ERK.