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Pathways of apoptosis. Apoptosis occurs via the receptor-mediated pathway (green) or mitochondrial pathway (grey). Proapoptotic genes are shown in blue. Intracellular signals (black) activating caspase-2 may also initiate the mitochondrial pathway. Sepsis induces apoptosis in an organism and model-specific manner, in which multiple components of each pathway are affected. Both pathways converge at active caspase-3 which initiates cell death.
