. Author manuscript; available in PMC: 2014 Mar 21.

Published in final edited form as: Rheumatology (Sunnyvale). 2012 Dec 26;2:113. doi: 10.4172/2161-1149.1000113

Table 3.

U-STAT3 and p-STAT3 in normal juvenile chondrocyte pellet cultures (N-JHu-C) and pellet cultures initiated from MSCs (BMD-MSC-C).

Macroaggregate PC	Treatment	U-STAT3	p-STAT3
N-JHu-C	No Addition	+	-
	rhTNF-α	↑ ^*	↑ ^*
	MSU	↑ ^*	↑ ^*
	AG-490	↑ ^*	↑ ^*
	rhTNF-α + AG-490	↓ ^**	↓ ^**
	MSU + AG-490	↓	↓ ^**
BMD-MSC-C	No Addition	+	-
	MSU	↔ ^*	↔ ^*
	MSU+AG-490	↑ ^**	↔ ^**
	MSU+AG-490+Febuxostat	↑ ^**	↑ ^**
	rhTNF-α	↑ ^*	↑ ^*
	rhTNF-α+AG-490+Febuxostat	↓ ^**	↔ ^**

Increase (↑), Decrease (↓), No Difference (↔) compared to No Addition

^**

Increase (↑), Decrease (↓), No Difference (↔) compared to MSU, AG-490 or rhTNF-α