Table 4.
Variants in the Mitochondrial tRNA Genes in 80 Chinese Subjects With Coronary Heart Disease and 512 Controls
| Genes | Position | Replacement | Conservation Index (%)* | WC Base Pairs* | Number of 80 Patients (%) | Number of 512 Controls (%) | χ2 P Value | Number of 2704 mtDNAs* (%) | χ2 P Value |
|---|---|---|---|---|---|---|---|---|---|
| tRNAGln | 4386 | T to C | 75 | 1 (1.25) | 4 (0.78) | 0.517 | 51 (1.89) | 1.000 | |
| tRNAAla | 5592 | A to G | 100 | C‐G↑ | 1 (1.25) | 0 (0) | 0.135 | 3 (0.11) | 0.110 |
| 5601 | C to T | 50 | 2 (2.5) | 15 (2.9) | 0.709 | 37 (1.39) | 0.309 | ||
| tRNACys | 5821 | G to A | 62.5 | C‐G↓ | 1 (1.25) | 12 (2.3) | 1.000 | 14 (0.52) | 0.355 |
| tRNAAsp | 7546 | T to C | 100 | 1 (1.25) | 0 (0) | 0.135 | 0 (0) | 0.029 | |
| tRNAGly | 10005 | A to G | 87.5 | 1 (1.25) | 0 (0) | 0.135 | 3 (0.11) | 0.110 | |
| 10007 | T to C | 43.8 | 1 (1.25) | 0 (0) | 0.135 | 4 (0.15) | 0.136 | ||
| tRNAArg | 10454 | T to C | 50 | 1 (1.25) | 4 (0.78) | 0.517 | 11 (0.4) | 0.269 | |
| tRNAHis | 12172 | A to G | 93.8 | 1 (1.25) | 5 (0.98) | 0.583 | 31 (1.15) | 0.609 | |
| tRNAGlu | 14687 | A to G | 93.8 | 1 (1.25) | 1 (0.20) | 0.252 | 22 (0.81) | 0.490 | |
| 14693 | A to G | 100 | 2 (2.5) | 7 (1.37) | 0.349 | 10 (0.37) | 0.045 | ||
| tRNAThr | 15889 | T to C | 18.8 | U‐A↓ | 2 (2.5) | 1 (0.20) | 0.049 | 3 (0.11) | 0.008 |
| 15927 | G to A | 68.8 | G‐C↓ | 4 (5) | 7 (1.37) | 0.048 | 44 (1.62) | 0.047 | |
| 15928 | G to A | 68.8 | G‐C↓ | 1 (1.25) | 2 (0.39) | 0.354 | 132 (4.88) | 0.181 | |
| 15930 | G to A | 12.5 | 4 (5) | 5 (0.98) | 0.023 | 37 (1.39) | 0.029 | ||
| 15951 | A to G | 56.25 | A‐U↓ | 1 (1.25) | 2 (0.39) | 0.354 | 22 (0.81) | 0.490 |
*
The conservation index (CI) was then defined as the percentage of the human nucleotide variants with 16 other vertebrates that had the wild‐type nucleotide at that position.
*
Classic Watson–Crick (WC) base pair: created (↑) or abolished (↓).