Table 4.
Effect of Exogenous Insulin on Platelets Activation While Intralipid Infusion
| Agents That Added | Controls (n=12) | PCOS (n=13) | ||||
|---|---|---|---|---|---|---|
| 2‐Hour Intralipid | 5‐Hour Intralipid | P Value | 2‐Hour Intralipid | 5‐Hour Intralipid | P Value | |
| Percentage of platelets expressed fibrinogen binding | ||||||
| Basal | 2.50 (2.34, 2.89) | 2.53 (2.08, 2.96) | 1.00 | 2.35 (2.20, 2.65) | 2.35 (2.2, 2.8) | 0.92 |
| +1 μmol/L ADP | 78.7 (67.9, 82.3) | 62.8 (51.8, 73.3) | 0.02 | 71.8 (58.7, 81.0) | 68.5 (56.3, 74.3) | 0.17 |
| +0.01 μmol/L PGI2+1 μmol/L ADP | 67.6 (39.5, 83.8) | 40.9 (23.8, 60.9) | 0.01 | 34.9 (17.1, 50.9) | 31.8 (21.4, 45.4) | 0.38 |
| +0.05 μmol/L PGI2+1 μmol/L ADP | 20.9 (4.45, 36.3) | 6.78 (3.06, 26.8) | 0.05 | 3.30 (2.75, 6.48) | 4.10 (2.5, 6.1) | 0.40 |
| +50 μmol/L 8CPT cAMP+1 μmol/L ADP | 68.5 (58.6, 72.8) | 54.0 (46.3, 67.1) | 0.02 | 50.2 (43.4, 67.0) | 55.2 (48.5, 59.5) | 0.75 |
| Percentage of platelets expressed P‐selectin | ||||||
| Basal | 1.90 (1.65, 2.61) | 2.48 (1.95, 3.29) | 0.11 | 1.70 (2.50, 2.18) | 2.40 (1.78, 3.40) | 0.13 |
| +1 μmol/L ADP | 54.1 (31.5, 63.4) | 41.3 (28.0, 46.8) | 0.04 | 44.9 (35.5, 54.6) | 44.4 (37.4, 60.1) | 0.97 |
| +0.01 μmol/L PGI2+1 μmol/L ADP | 49.6 (26.4, 65.8) | 30.3 (12.5, 46.0) | 0.01 | 28.3 (13.6, 37.1) | 22.3 (18.7, 40.0) | 0.70 |
| +0.05 μmol/L PGI2+1 μmol/L ADP | 15.6 (3.15, 23.6) | 8.70 (3.65, 22.5) | 0.31 | 5.95 (4.00, 11.2) | 7.70 (5.10, 12.7) | 0.51 |
| +50 μmol/L 8CPT cAMP+1 μmol/L ADP | 45.8 (27.5, 55.9) | 35.4 (27.9, 41.0) | 0.02 | 27.9 (20.0, 48.5) | 36.7 (29.2, 45.0) | 0.13 |
Results are expressed as medians (IQR), P value ≤0.05 is significance of difference. Wilcoxon signed ranks test. ADP indicates adenosine diphosphate; cAMP, cyclic adenosine monophophate; PCOS, polycystic ovary syndrome; PGI2, prostacyclin.