Figure 7.

Diagram depicting the proposed effects of activating autoantibodies (AAb) on the pathophysiology of POTS. These conclusions are supported by data demonstrating the consistent presence of autoantibodies to the α1AR, the β1AR, and variably the β2AR. The differing allosteric impact on their respective receptors will lead to an exaggerated tachycardia characteristic of this common syndrome. AR indicates adrenergic receptors; BP, blood pressure; NE, norepinephrine; POTS, postural tachycardia syndrome.