Table 4.

Ranges of doses of phosphate supplements and vitamin D analogs throughout life, and their respective markers of efficacy and safety as applied in our center.

Period	Phosphate supplements	Vitamin D analogs (alfacalcidol only a )	Surveillance for efficacy and safety	Frequency
Infancy (dose) divided into	55–70 mg/kg per day	1.5–2.0 μg/day once/day	Clinical: height, weight, cranial circumference	Every 3 months
	four times/day		Blood: alkaline phosphatases, total calcium, PTH, creatinine
			Urines (spot): calcium/creatinine
Childhood (dose) divided into	45–60 mg/kg per day	1.0–2.0 μg/day	Clinical: height, weight, leg bowing, teeth	Every 6 months
	three times/day	once/day	Blood: alkaline phosphatases, total calcium, PTH, creatinine	Every 6 months
			Urines (24-h): calciuria, phosphaturia	Every 3 months
			Renal ultrasound	Every year
Puberty (dose) divided into	35–50 mg/kg per day	1.5–3.0 μg/day	Clinical: height, weight, leg bowing, teeth	Every 6 months
	three times/day	once/day	Blood: alkaline phosphatases, total calcium, PTH, creatinine	Every 6 months
			Urines (24-h): calciuria, phosphaturia	Every 3 months
			Renal ultrasound	Every year
Adulthood (dose) divided into	0–2000 mg/day	0–1.5 μg/day	Clinical: weight, mobility, pain, teeth	Every year
	two times/day	once/day	Blood: bone alkaline phosphatases, total calcium, PTH, creatinine	Every year
			Urines (24-h): calciuria	Every 6 months
			Renal ultrasound	Every other year
Pregnancy (dose) divided into	2000 mg/day	1–1.5 μg/day	Clinical: weight, mobility, pain	Every 3 months
	two times/day	once/day	Blood: total calcium, PTH, creatinine, 25-OH vitamin D	Every 3 months
			Urines (24-h): calciuria	Every 3 months
Menopause (dose) divided into	0–2000 mg/day	0–1.5 μg/day	Clinical: weight, mobility, pain, teeth	Every year
	two times/day	once/day	Blood: bone alkaline phosphatases, total calcium, PTH, creatinine	Every year
			Urines (24-h): calciuria	Every 6 months
			Renal ultrasound	Every other year

^aEquivalent dose in calcitriol was obtained divided by a factor 2.