Table 3.

General population cohorts. Pooled adjusted hazard ratios (95% confidence intervals) for end-stage renal disease and acute kidney injury and pooled adjusted odds ratios (95% confidence intervals) for progressive chronic kidney disease. Shaded areas make up the combined reference groups.

		albumin-to-creatinine ratio (mg/g) or dipstick (classes)
		<10 Negative	10–29 trace	30–299 1+	≥300 ≥2+	All
End-Stage Renal Disease
eGFR mL/min/1.73m2	>105			7.8 (1.7–35.9)	18.1 (4.30–75.9)
	90–104	Ref		11.3 (2.7–47.7)	19.7 (5.84–66.5)	Ref
	75–89			3.83 (1.2–12.3)	48.1 (28.1–82.3)
	60–74			7.42 (3.6–15.2)	67.2 (40.1–113)
	45–59	5.2 (3.3–8.0)	21.8 (12.0–39.6)	40.3 (23.5–69.2)	147 (98.7–219)	9.67 (7.07–13.2)
	30–44	55.5 (36.0–85.6)	74.1 (29.3–187)	293 (199–433)	763 (563–1035)	98.1 (61.8–156)
	15–29	433 (239–787)	1044 (524–2077)	1056 (572–1948)	2286 (1114–4695)	573 (241–1362)
	All	Ref		12.0 (7.9–18.1)	72.1 (43.0–121)
Acute Kidney Injury
eGFR mL/min/1.73m2	>105			2.7 (0.9–8.5)	8.4 (5.1–13.8)
	90–104	Ref		2.4 (1.1–5.2)	5.8 (3.7–9.2)	Ref
	75–89			2.5 (1.9–3.4)	4.1 (2.8–5.9)
	60–74			3.3 (2.6–4.1)	6.4 (5.0–8.2)
	45–59	2.2 (2.0–2.5)	4.9 (3.3–7.3)	6.3 (4.8–8.4)	5.9 (2.4–14.5)	2.6 (2.2–3.1)
	30–44	7.3 (6.5–8.2)	10.2 (5.9–17.5)	12.4 (10.2–15.2)	19.6 (16.5–23.2)	7.9 (7.1–8.7)
	15–29	16.8 (14.0–20.2)	16.8 (11.3–25.1)	21.4 (16.5–27.8)	28.8 (23.7–35.1)	16.7 (14.7–18.9)
	All	Ref		2.5 (1.7–3.7)	6.0 (4.5–8.0)
Progressive Chronic Kidney Disease
eGFR mL/min/1.73m2	>105			0.7 (0.7–0.8)	3.0 (0.4–23.7)
	90–104	Ref		0.9 (0.4–2.1)	3.3 (0.5–23.3)	Ref
	75–89			1.9 (0.6–5.6)	5.0 (0.9–27.1)
	60–74			3.2 (1.4–7.5)	8.1 (5.2–12.8)
	45–59	3.1 (1.6–6.0)	4.0 (1.9–8.8)	9.4 (3.7–23.7)	56.6 (4.2–767.6)	3.9 (1.9–7.8)
	30–44	3.0 (1.2–7.5)	19.1 (19.0–19.2)	14.9 (2.8–78.5)	22.2 (4.8–103.6)	3.7 (1.1–12.3)
	15–29	4.0 (3.9–4.0)	11.7 (11.6–11.9)	21.0 (4.5–99.5)	7.7 (2.9–20.6)	7.9 (3.0–21.2)
	All	Ref		3.1 (2.5–3.8)	11.2 (5.8–21.5)

Abbreviations are: eGFR. estimated glomerular filtration rate.