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. Author manuscript; available in PMC: 2014 Jun 27.
Published in final edited form as: J Med Chem. 2013 Jun 7;56(12):4880–4898. doi: 10.1021/jm400048v

Scheme 2.

Scheme 2

Synthesis of C-16 substituted compounds (25, 28 and 31)a

aReagents and conditions: (i) substituted amines, molecular sieves, EtOH, Ar, reflux (3 – 7 h); (ii) MeOH, NaBH4, ice cold (2 h), rt (3 h); (iii) MeOH, 10% methanolic-KOH, Ar, rt (2 – 3 h);