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. 2014 Mar 19;6(2):e00140. doi: 10.1042/AN20140006

Figure 10. Presynaptic and postsynaptic component of striatal synaptic plasticity induced by de Cdk5 inhibitor Roscovitine.

Figure 10

(A) Temporal course of EPSC after HFS in the presence of Roscovitine in the recording pipette (10 μM). HFS protocol induced LTD. (B) Representative traces of EPSC in the presence of Roscovitine in the recording pipette. (C) Temporal curse of EPSC in the presence of Roscovitine (20 μM) in the recording bath and H89 (5 μM) in the recording pipette. Note that there were no changes in EPSC amplitude after HFS protocol. (D) Representative traces of EPSC in the presence of Roscovitine (20 μM) in the recording bath and H89 (5 μM) in the recording pipette.