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. Author manuscript; available in PMC: 2014 Mar 19.
Published in final edited form as: Neurobiol Dis. 2013 Jan 17;54:349–361. doi: 10.1016/j.nbd.2013.01.006

Fig. 8.

Fig. 8

An increase in damaged mitochondria in BA21 ASD postmortem brain. Layer V pyramidal neurons (10–20 neurons per case) were immunolabeled for porin, SOD2, and COX2. Scale bar, 10 μm. (A) Representative images for immunohistochemistry of porin, SOD2, COX2 in temporal lobe layer V pyramidal neurons. (B) Quantification of porin, SOD2 and COX2 immunofluorescent intensity in pyramidal neurons in temporal lobe layer V from ASD patients and controls. Compared to control subjects, ASD patients showed a decrease in SOD2, COX2 intensity, but an increase in porin fluorescence. Control, n=7; ASD, n=8. Compared to controls, *p<0.05, **p<0.01. (C) Protein levels of mitochondria respiratory chain proteins and SOD2, normalized to the level of mitochondrial outer membrane protein Tom20. Control, n=7; ASD, n=8. Compared to controls, *p<0.05, **p<0.01.