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. Author manuscript; available in PMC: 2014 Mar 19.
Published in final edited form as: Nat Rev Neurol. 2013 Jul 9;9(8):429–444. doi: 10.1038/nrneurol.2013.126

Figure 4.

Figure 4

Muscle biopsy in patients with mitochondrial disease. a | In a patient with MERRF (harbouring a mitochondrial DNA point mutation that impairs mitochondrial protein synthesis), two ragged-red fibres are evident with the modified Gomori trichrome stain. b–d | Using the SDH stain, the same fibres appear ‘ragged blue’ (part b) but are COX-negative (part c), and stain blue with the combined COX and SDH stain (COX-deficient fibres stain a lighter blue; part d). Abbreviations: MERRF, myoclonus epilepsy with ragged-red fibres; SDH, succinate dehydrogenase. Image first printed in Molecular Neurology.155