Table 4. Enantioselective addition of alkynes to N-benzylideneaniline.
Entry | Alkyne | Solvent/temperature °C/time, days | Yield, % | OR/ee % |
---|---|---|---|---|
1 | n-C3H7CCH | Neat/22/4 | 55 | (+) 71 |
2 | Et3SiCCH | Toluene/22/4 | 53 | (+) 60 |
3 | Cl(CH2)4CCH | Toluene/22/4 | 48 | (+) 65 |
4 | HO(CH2)4CCH | Toluene/22/4 | 62 | (+) 85 |
5 | HO(CH2)2CCH | Toluene/22/4 | 58 | (-) 82 |