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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Hippocampus. 2014 Feb;24(2):178–188. doi: 10.1002/hipo.22213

Figure 4.

Figure 4

Acute administration of JWH-081 impairs novel object recognition memory in adult mice. (A) The level of exploration was measured at el and e2 (1 or 4 or 24 hrs), and the time spent exploring the two objects was measured at T1 and T2 (at 1, 4 and 24 hrs) in WT or KO mice treated with vehicle or JWH-081. (B–D) Discrimination indices (d2) obtained from the WT or KO mice treated with vehicle or JWH-081 at 1 (b), 4 (c) and 24 hrs (d) retention intervals. ***p < 0.001 vs. CB1WT + Vehicle; # p < 0.05 vs. CB1WT + Vehicle; $ p < 0.05 vs. CB1WT + JWH-081; @ p < 0.001 vs. CB1WT + Vehicle. (E) The level of exploration was measured at el and e2 (1 or 4 hrs), and the time spent exploring the two objects was measured at T1 and T2 (at 1 and 4 hrs) in C57BL/6J mice pretreated with vehicle or SR and treated with vehicle or JWH-081. (F and G) Discrimination indices (d2) obtained from the SR pretreated mice treated with vehicle or JWH-081 at 1 (F), 4 hrs (G) retention intervals. One-way ANOVA with Bonferroni’s post hoc test; ***p < 0.001 vs. Vehicle; # p < 0.05 vs. Vehicle; $ p < 0.05 vs. or JWH-081; @ p < 0.001 vs. Vehicle.