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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Hippocampus. 2014 Feb;24(2):178–188. doi: 10.1002/hipo.22213

Figure 5.

Figure 5

Acute administration of JWH-081 impairs spontaneous alternation performance in adult mice. (A) Spatial working memory of CB1 receptor WT and KO mice treated with or without JWH-081 was tested using spontaneous alternation performance in the Y-maze. Note that JWH-081 treated WT mice perform poorly (well below 50% chance levels) compared to WT mice treated with vehicle (*** p < 0.001). Overall, KO mice treated with either vehicle or JWH-081 show significantly enhanced levels of alternation performance (# p < 0.05 versus CB1WT + V; @ p < 0.05 versus CB1WT + V; $ p < 0.05 versus CB1WT + JWH-081) when compared to WT mice with or without JWH-081 treatment. (B) The number of arm entries was not different between WT and KO mice (p > 0.05) but JWH-081 treatment enhanced the number of arm entries in both WT (*** p < 0.001 versus CB1WT + V) and KO mice (*** p < 0.001 versus CB1KO + V). (C) The time spent in each arm was not different between WT and KO mice (p > 0.05) with or without JWH-081 treatment (p > 0.05 versus CB1WT + V). Each point is the mean ± SEM (n= 8 mice/group). One-way ANOVA with Bonferroni’s post hoc test.