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. 2014 Feb 20;7:29–38. doi: 10.2147/JIR.S55672

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© 2014 Yoo et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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AD characteristic histologic changes in OVA challenged mice. (A) Histology was analyzed at 1, 3, and 7 days of challenge and compared to skin of untreated mice, revealing a progression of characteristic histologic changes, including acanthosis, spongiosis, hyperkeratosis, dermal inflammation, and dermal thickening. Images, shown at 20× (upper) and 40× (lower) magnifications, are representative of three mice per time point. (B) Secondary changes included erosion, crust, and impetiginization.

Abbreviations: AD, atopic dermatitis; OVA, ovalbumin.